ANTI-INFLAMMATORY AND ANTI-NOCICEPTIVE PROPERTIES OF AQUEOUS LEAVES EXTRACT OF IPOMOEA BATATAS (LAM). ON EXPERIMENTAL ANIMALS

Benjamin Ogunma Gabriel, Emmanuel Ola Oshomoh, Odega I. Kevin

Abstract

Ipomoea batatas is sub-tropical and tropical region plant being implicated in the treatment of several diseases as reported ethnomedicinally. Leaves aqueous extract of I. batatas was evaluated for the potential of anti-inflammatory and anti-nociceptive properties of Wistar rats and mice. These autonomous studies, involving two phases of the study of which twenty-five rats and mice were randomly divided into groups of five (n=5). The studies involved formalin induced antiinflammatory effect in rats exhibiting edema on left hind sub-planter paw. Acetic acid and hot plate induced pain in mice were evaluated via peripheral and central acting anti-nociceptive property of Ipomoea batatas plant extract. The extract was orally given across the treated groups at graded doses: 50, 100 and 200 mg/kg with aspirin and pentazocin as reference drug control whereas untreated control was given water. The results gotten showed a significant reduction (p<0.05) in the paw volume of the plant extract with anti-inflammatory property was observed at 120, 180 and 240 minutes. From the anti-nociceptive activity, a significant inhibitory effect (p<0.05) across the treated groups with formalin and hot plate induced pain in mice. This research study hence authenticates the folklore benefits of I. batatas leaves in treating inflammation and nociceptives. Read full PDF

Keywords: Ipomea batatas; antiinflammatory; anti-nociceptive, pentazocin, aspirin

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